Camiguin was part of Misamis Oriental from 1946 to 1958. Then in 1958, it became a sub-province and in 1968, a full-fledged province with Mambajao as its provincial capital.

In 1980, Camiguin School of Arts and Trade was established as a Secondary Trade School. Central Mindanao University and Mindanao Polytechnic State College also established Satellite Schools in the Province.

Seeing the need to establish a State College that would cater to the needs of the youth of the province, Congressman Pedro P. Romualdo authored Republic Act 7923 which was presented in congress on July 25, 1994.

On Febuary 24, 1995, by virtue of Republic Act 7923, the Mindanao Polytechnic State College-Camiguin Campus, Central Mindanao University-Catarman Campus and Camiguin School of Arts and Trades, were integrated into one State College, the Camiguin Polytechnic State College with its Main Campus located at Balbagon, Mambajao, Camiguin.

After a Brief transition period, CPSC officially opened its door to higher education in June 1996.

From then on, CPSC has been under the Leadership of the following Presidents:

To date, CPSC strives to provide professional, technical and special instruction for special purposes and to promote research and extension services, advanced studies and progressive leadership in Agriculture, Forestry, Engineering, Arts and Sciences, and other relevant studies through quality instruction.

CPSC offers the following Curriculum:
1. Graduate Studies
a. Master of Arts in Education
b. Master in Public Administration
2. Institute of Education
a. Bachelor in Secondary Education
-major in Biology
-major General Science
-major in English
-major in Technology and Livelihood Education
c. Complete Secondary Laboratory School
3. Institute of Nursing
a. Bachelor of Science in Nursing
b. 6 Month Caregiving NC II
4. Institute of Technology
a. Two-Year Certificate of Technology with majors in Automotive, Construction, Electrical, Electronics and Garment Technology
b. Bachelor of Technology (Ladderized Curriculum) with majors in Automotive, Construction, Electrical, Electronics and Garment Technology
5. Institute of Engineering
b. Bachelor of Science in Electrical Engineering
c. Bachelor of Science in Electronics and Communication Engineering
6. Institute of Computer Studies
a. Bachelor of Science in Computer Science
b. Bachelor of Science in Information Technology
7. Institute of Arts & Sciences
a. Bachelor of Science in Biology
- major in Marine Biology
b. Bachelor of Science in Eco-Tourism
c. Bachelor of Arts in Business Management
d. Bachelor of Arts in Public Administration
e. Bachelor of Arts in English
8. Institute of Agriculture
a. Bachelor of Science in Agriculture
- major in Agricultural Education
- major in Crop Science
- major in Agroforestry
- major in Animal Science
b. Bachelor in Elementary Education